Clinically validated for tis hypolipidemic effect to help healthy lipid profiles
Well recognized for its Cardiovascular benefits
Help manage healthy cholesterol levels
Mechanism of Action
The hypolipidemic activity of Guggulsterones could be attributed to several mechanisms including inhibition of cholesterol biosynthesis and enhancement in cholesterol degradation and/ or excretion.
Guggulsterones E and Z act as antagonists at the farnesoid X receptor, allowing more cholesterol catabolism and excretion from the body. This receptor mediates the conversion of cholesterol to bile acids; by antagonizing this receptor, 7α-hydroxylase is released, stimulating cholesterol catabolism. This helps to maintain the cholesterol and bile acid homeostasis accounting for itshypolipidemic activity.
Another mechanism proposed is that Guggulsterone upregulates the expression of the bile salt export pump (BSEP), a rate-limiting efflux transporter for eliminating cholesterol metabolites bile acids from the liver. Such upregulation is possibly mediated through the activating protein 1 (AP-1) signaling pathway The FXR antagonism and enhanced BSEP expression have been proposed as possible mechanisms for the hypolipidemic effect of guggulsterone
Guggul markedly inhibits liver cholesterol biosynthesis. This causes interference in lipoprotein formation and lipid turnover.
Guggulincreases fecal excretion of bile acids (cholic and deoxycholic acids) & cholesterol and lowers intestinal absorption of fat and cholesterol. Guggul stimulates the LDL receptor binding activity in hepatocytes and enhances its catabolism.Guggulsterones have the capability of inhibitingoxidative modification of LDL.
