Guggul Extract

Botanical name: Commiphora mukul

Common name: Guggul / Guggulsterones

Standardized for: Guggulsteronesby HPLC or UV

Our Guggul Range

Guggul Extract

  • NLT2.5% Guggulsterones E&Z by HPLC
  • NLT10.0 % Guggulsterones E&Z by UV

Structure of Guggulsterones
Key Health Benefits

  • Clinically validated for tis hypolipidemic effect to help healthy lipid profiles
  • Well recognized for its Cardiovascular benefits
  • Help manage healthy cholesterol levels


Mechanism of Action

  • The hypolipidemic activity of Guggulsterones could be attributed to several mechanisms including inhibition of cholesterol biosynthesis and enhancement in cholesterol degradation and/ or excretion. 
  • Guggulsterones E and Z act as antagonists at the farnesoid X receptor, allowing more cholesterol catabolism and excretion from the body. This receptor mediates the conversion of cholesterol to bile acids; by antagonizing this receptor, 7α-hydroxylase is released, stimulating cholesterol catabolism. This helps to maintain the cholesterol and bile acid homeostasis accounting for itshypolipidemic activity.
  • Another mechanism proposed is that Guggulsterone upregulates the expression of the bile salt export pump (BSEP), a rate-limiting efflux transporter for eliminating cholesterol metabolites bile acids from the liver. Such upregulation is possibly mediated through the activating protein 1 (AP-1) signaling pathway The FXR antagonism and enhanced BSEP expression have been proposed as possible mechanisms for the hypolipidemic effect of guggulsterone
  • Guggul markedly inhibits liver cholesterol biosynthesis. This causes interference in lipoprotein formation and lipid turnover. 
  • Guggulincreases fecal excretion of bile acids (cholic and deoxycholic acids) & cholesterol and lowers intestinal absorption of fat and cholesterol. Guggul stimulates the LDL receptor binding activity in hepatocytes and enhances its catabolism.Guggulsterones have the capability of inhibitingoxidative modification of LDL. 


Mechanism of Action

  1. R. DengTherapeutic Effects of Guggul and Its Constituent Guggulsterone: Cardiovascular Benefits - Deng - 2007 - Cardiovascular Drug Reviews - Wiley Online LibraryCardiovascular Drug Reviews, Vol. 25, No. 4, 2007
  2. Saggam et al., Withaniasomnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management - PubMed ( Pharmacol. 12:623795
  3. VivekVermaet al.,(PDF) Systematic review of anti-viral & immunomodulatory potential of Ashwagandha (WithaniaSomnifera. Linn) in light of covid-19 pandemic ( Journal of Botany Studies, Volume 5; Issue 5; 2020; Page No. 494-497.
  4. Langade D, Kanchi S, Salve J, et al. (September 28, 2019) Efficacy and Safety of Ashwagandha (Withaniasomnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study - PubMed ( 11(9): e5797. DOI 10.7759/cureus.579
  5. Wankhede et al. Examining the effect of Withaniasomnifera supplementation on muscle strength and recovery: a randomized controlled trial - PubMed ( of the International Society of Sports Nutrition (2015) 12:43
  6. Tharakan, A.; Shukla, H.; Benny, I.R.; Tharakan, M.; George, L.; Koshy, S. Immunomodulatory Effect of Withaniasomnifera (Ashwagandha) Extract—A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy ParticipantsJ. Clin. Med. 2021, 10, 3644
  7. Deng R, Yang D, Radke A, Yang J, Yan B (2007) The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: Dominance of transactivation over farsenoid X receptor-mediated antagonism.J PharmacolExpTher 320:1153-1162


Copyright © 2021.Dr. Willmar Schwabe India Pvt. Ltd.. All Rights Reserved