Ashwagandha Extract

NLT 2.5% Withanolides by HPLC NLT 5.0% Withanolides by HPLC NLT 2.5% Withanolides by Gravimetry NLT 5.0% Withanolides by Gravimetry

• Clinically validated to improve the immune profile of healthy subjects by modulating the innate and adaptive immune systems.
• Boost the immune system of people at risk of infection and during widespread infections
• Helps manage stress and anxiety in adults.
• Clinically studies to improve sleep quality and manage insomnia
• Improve variables related to strength/power, cardiorespiratory fitness and fatigue/recovery in healthy men and female…. Recommending it as a sport nutrient.

 

Improving Immunity - improves the body's defense against disease by improving the cell-mediated immunity.

Anti-stress – Managing cortisol level

Anti-oxidant - by increasing the activities of cellular antioxidant enzymes (superoxide dismutase [SOD]; catalase [CAT]; glutathione S-transferase [GST]; heme oxygenase 1 [HO-1]; NADPH dehydrogenase, quinone 1 [NQO1]; nuclear factor E2-related factor 2 [Nrf2,])

Anti-inflammatory - by inhibiting prostaglandin (PGE2) synthesis by cyclooxygenase-2 (COX-2) and nitric oxide production by inhibiting nitric oxide synthase (iNOS) and release of interleukins (IL-6 and IL-1β) and nuclear factor κ light chain enhancer of activated B cells (NFκB).

Sexual health – by helping to reduce oxidative stress and improve the antioxidant potential of seminal plasma;  Also by preventing the stress induced cortisol-mediated decrease in testosterone level, as well as exerts an inhibitory action of prolactin on sperm production. These mechanisms normalize the male reproductive hormone levels and improve sperm parameters to enhance male fertility.

1. Immunomodulatory Potential of New Classical Herbomineral Formulation in Experimental Animals: Impact of Biofield Energy Healing Treatment
2. Effect of a Novel Ashwagandha-based Herbomineral Formulation on Pro-inflammatory Cytokines Expression in Mouse Splenocyte Cells: A Potential Immunomodulator
3. Immunopotentiating Impact of The Trivedi Effect -Biofield Energy Healing on Herbomineral Formulation After Oral Administration in Male Sprague Dawley Rats
4. Longevity and healthy ageing genes FOXO3A and SIRT3: Serum protein marker and new road map to burst oxidative stress by Withania somnifera
5. The effect of Ashwagandha (Withania Somnifera) on anaerobic performance on elite Indian cyclist
6. Effects of eight-week Supplementation of Ashwagandha on Cardiorespiratory Endurance in Elite Indian Cyclists

1. Salve J, Pate S, Debnath K, et al. (December 25, 2019) Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study - PubMed (nih.gov) Cureus 11(12): e6466. DOI 10.7759/cureus.6466
2. Saggam et al., Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management - PubMed (nih.gov) Front. Pharmacol. 12:623795
3. Vivek Verma et al., (PDF) Systematic review of anti-viral & immunomodulatory potential of Ashwagandha (Withania Somnifera. Linn) in light of covid-19 pandemic (researchgate.net) International Journal of Botany Studies, Volume 5; Issue 5; 2020; Page No. 494-497.
4. Langade D, Kanchi S, Salve J, et al. (September 28, 2019) Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study - PubMed (nih.gov) Cureus 11(9): e5797. DOI 10.7759/cureus.579
5. Wankhede et al. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial - PubMed (nih.gov) Journal of the International Society of Sports Nutrition (2015) 12:43
6. Tharakan, A.; Shukla, H.; Benny, I.R.; Tharakan, M.; George, L.; Koshy, S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract—A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants J. Clin. Med. 2021, 10, 3644
7. Dhar et al. A Decade of Molecular Understanding of Withanolide Biosynthesis and In vitro Studies in Withania somnifera (L.) Dunal: Prospects and Perspectives for Pathway Engineering - PubMed (nih.gov) Front. Plant Sci. November 2015 | Volume 6 | Article 1031
8. Lopresti et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study - PubMed (nih.gov) Medicine (2019) 98:37