Garcinia Extract

NLT 50% HCA by HPLC NLT 60% HCA by HPLC

• Clinically validated for its potential use in weight management

It is reported that HCA reduces weight gain by inhibiting ATP citrate lyase, an enzyme which catalyzes the extra-mitochondrial cleavage of citrate to oxaloacetate and acetyl coenzyme A (acetyl-CoA), a building block of fatty acid synthesis.

By reducing the levels of acetyl-CoA and subsequently malonyl-CoA pool HCA limits the synthesis of fats and cholesterol.

The overall impact of this results in

• Suppression of food intake
• Decrease in de novo lipogenesis
• Increase in oxidation of  fatty acids
• Reduction in glucose intake rates in tissues.

1. Development and Validation of High-Performance Thin-Layer Chromatographic Method for Determination of α-Mangostin in Fruit Pericarp of Mangosteen Plant (Garcinia mangostana L.) using Ultraviolet   Visible Detection
    
2. Rapid Determination & Standardization of Garcinia Fruit Extract of Hydroxycitric acid (HCA) in Garcinia cambogia by HPLC

1. Manu Tomar, Raghavendra Prahlad Rao, Palaniyamma Dorairaj, Abhishek Koshta, Sowbhagya Suresh, Mohamed Rafiq, Rajesh Kumawat, Rangesh Paramesh, Babu U. V and K. V. Venkatesh A clinical and computational study on anti-obesity effects of hydroxycitric acid RSC Adv., 2019, 9, 18578
2. Igho Onakpoya, Shao Kang Hung, Rachel Perry, Barbara Wider, and Edzard Ernst., The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials Journal of Obesity, Volume 2011, Article ID 509038, 9 pages
3. Li Oon Chuah, Wan Yong Ho, Boon Kee Beh and Swee Keong Yeap., Updates on Antiobesity Effect of Garcinia Origin (−)-HCA Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 751658, 17 pages