Colchicine to meet USP

Colchicine to meet BP

• A pharmaceutical approved ingredient used in the treatment of Gout… and is taken as prescribed by Doctors

Gout is an inflammatory arthritis caused by the precipitation of serum urate into crystallizeddeposits of monosodium urate in and aroundthe joint. Triggered by a variety of interactions between monosodium urate crystals and the surface of cells, there can be recurrent episodes ofsevere inflammatory arthritis which manifests as swelling,redness, heat, pain, and stiffness in the joints, mostoften seen in the first metatarsophalangeal joint.

Colchicine modulates multiple proand anti-inflammatory pathways associated with goutyarthritis. Colchicine exhibits a multimodal mechanism of actions,which work to prevent microtubule assemblyand thereby disrupts inflammasome activation,microtubule-based inflammatory cell chemotaxis, generation of leukotrienes and cytokines, and phagocytosis.

 

1. Leung et al. Colchicine --- update on mechanisms of action and therapeutic useSemin Arthritis Rheum. 2015 December ; 45(3): 341–350
    
2. N. Dalbeth et al., Mechanism of Action of Colchicine in the Treatment of GoutClinical Therapeutics/Volume 36, Number 10, 2014