Botanical name: Gloriosa superba

Common name: Gloriosa superba

Standardized for: Meets IP / FP / EP

Our Thiocolchicoside Range

Thiocolchicoside IP

Thiocolchicoside FP

Thiocolchicoside EP

Structure of Thiocolchicoside
Key Health Benefits

  • A pharmaceutical approved ingredient used as muscle relaxant and is used as prescribed by Doctors


Mechanism of Action

  • Thiocolchicoside: Uses, Interactions, Mechanism of Action | DrugBank Online
  • Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human cortex. GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation, and anesthetics. GABA can also modulate heart rate and blood pressure.
  • Glycine is an inhibitory neurotransmitter and acts as an allosteric regulator of NMDA (N-methyl-D-aspartate) receptors. It is involved in the processing of motor and sensory data, thereby regulating movement, vision, and audition.
  • Thiocolchicoside has a selective and potent af?nity for g-aminobutyric acid A (GABA-A) receptors and an affinity for the inhibitory glycine receptors. With this Glycomimetic and GABA mimetic activity it acts as a muscle relaxant.
  • It acts on muscular contractures by activating the GABA inhibitory pathways thereby behaving as a potent muscle relaxant

Published Literature Reference

  1. A.R Umarkar et al. THIOCOLCHICOSIDE AS MUSCLE RELAXANT: A REVIEW IJPBS,Volume 1,| Issue 3, JULY-SEPT-2011, 364-37
  2. C. Aksoy, A. Karan & D. D?raçog?lu., Low back pain: results of an open clinical trial comparing the standard treatment alone to the combination of standard treatment and thiocolchicoside J Orthopaed Traumatol (2002) 3:103–108
  3. Rajeev Rao et al. Clinical Comparative Study: Efficacy and Tolerability of Tolperisone and Thiocolchicoside in Acute Low Back Pain and Spinal Muscle Spasticity Asian Spine Journal Vol. 6, No. 2, pp 115~122, 2012


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